Early treatment is most important
Available treatments vary depending on when symptoms began and your physical condition. Not all patients receive the same treatment.
OSANG SPECIALTY CENTER
Stem Cell Clinic
Easily view external research papers
What has changed in cerebral
infarction stem cell research?
The papers published by the external research team have been organized in an easy-to-understand manner for patients and their guardians. We take a look at what's improving in research and what we still don't know. This is not the result of treatment at Osang Neurosurgery.
external thesis×Results commentary
Easily view cerebral infarction stem cell research papers
What has improved in cerebral
infarction stem cell research?
Some studies have reported improvements in the ability to move the body or live independently. However, the cells and methods used are different for each study, so the results cannot be viewed as the same treatment.
The information below provides a simple explanation of the external thesis. This does not mean that Osang Neurosurgery performs this treatment.
Things to know first
The treatment for cerebral infarction we are receiving now is different from the stem cell research.
For cerebral infarction, rapid initial treatment, management to prevent recurrence, and rehabilitation are the basics. Stem cell research does not replace these treatments.
Medication and lifestyle management lower the risk of recurrence
Taking medication and managing blood pressure, blood sugar, and cholesterol can help lower the risk of recurrence. It is not a treatment that returns an already injured brain to its original state.
Rehabilitation helps you get back to your daily life
Practice walking, using your arms, speaking and swallowing. Because the parts of the brain that are injured are different, the speed of recovery also varies from person to person.
How to view study resultsDifferent research methods
Different research methods
require different numbers.
The cells used, when they were added, and how they were added vary from study to study. Even if all stem cell research is conducted, it is not the same treatment.
Which cells were added and when?
We can see how long after a cerebral infarction occurred and which cells were put where.
Have you seen changes in your body and side effects?
We check whether walking, using arms and living alone have improved and whether there are any side effects.
Were there any other groups to compare it to?
Distinguishing the impact of spontaneous recovery or rehabilitation requires comparison with a group that received no treatment.
Major changes in the paper
- A compilation of 13 studies found that more people in the group that received cells had no significant problems in their daily lives a year later.
- In a study of 30 people, scores were better for paralysis, speech, arm and leg movement, and living alone.
- A study of 35 people showed improvements in some disability scores and arm movements.
What we cannot know from this study alone
- The cells used and method of introduction varied between studies.
- There were also results that made it difficult to know whether the differences occurred by chance due to the small number of participants.
- Long-lasting effects and side effects need to be confirmed through larger studies.
13 studies · 872 people in total · 2025
A year later, there were more people who had not
experienced any major disruptions in their daily lives.
Results were collected from 13 studies, a total of 872 people, who received cells within a month after cerebral infarction. Due to different study methods, these numbers may not apply equally to all patients.
- How many people participated?
- 13 studies, 872 people in total
- When did you add the cells?
- Within 1 month after cerebral infarction
- How did you look at it?
- Compare results from 13 studies together
- When did you see the results?
- 3 months later and 1 year later
Proportion of no major disruptions in daily life after one year23.1% / 12.8%Cell Group/Comparison Group
Group that received cells45/195 people
comparison group23/179 people
Proportion of people who were able to live on their own after 3 months32.6% / 26.1%Cell Group/Comparison Group
Group that received cells105/322 people
comparison group67/257 people
Total number of people participating in the study872 people in totalNumber of people combined from 13 studies with different methods
All participants872 people
research 01
If you solve it easily,
You can look at the result like this.
In the group that received the cells, the rate of no significant disruption in daily life after one year was 23.1%, compared to 12.8% in the comparison group. However, there were cases where the difference was not clear when the calculation method was changed. This number cannot predict a person's recovery in advance.
Original sourceView the original text and research information
Comprehensive analysis of comparative studies in the early stages of the outbreakScientific Reports · 2025 · 13 studiesIt remains to be seen if larger studies produce the same results. The mere fact that a medical institution has been designated as a specific institution does not prove the effectiveness of treatment.
30 people studied · 2014
In a study of 30 people, some scores were
better than those in the rehabilitation group.
Thirty patients six months to five years after cerebral infarction were divided into two groups. Fifteen people had cells from their own blood injected into their brains, and 15 received only general rehabilitation.
- How many people participated?
- 30 people, 15 cell group / 15 rehabilitation group
- How did you divide it?
- Divided into two groups like a lottery
- What did you do?
- Inserting cells (CD34+) from your own blood into the brain
- When did you see the results?
- 12 months later
A score that combines paralysis and speech discomfort5.5 points / 8.7 pointsCell group/rehabilitation group · The lower the level, the less discomfort
cell group5.5 points
general rehabilitation group8.7 points
Help needed when living alone2.1 points / 2.7 pointsCell Group/Rehabilitation Group · The lower the less help you need.
cell group2.1 points
general rehabilitation group2.7 points
Arm and leg movement scores30.5 points / 21.7 pointsCell group/rehabilitation group · The higher the level, the better the movement.
cell group30.5 points
general rehabilitation group21.7 points
research 02
If you solve it easily,
You can look at the result like this.
The group that received cells had better scores for paralysis, speech, movement, and daily living than the group that only received rehabilitation. However, there were only 30 participants, and the comparison group did not undergo the same surgery. Therefore, it is difficult to conclude that it is only a cellular effect.
Original sourceView the original text and research information
Chen research team's original paperCell Transplantation · 2014 · doi:10.3727/096368914X678562This study looked at only 30 people at one medical institution. This result alone cannot be considered a general treatment.
35 researchers · 2023
A study of 35 people showed
some improvement in scores.
Thirty-five patients aged 14 to 28 days after cerebral infarction were divided into two groups. One group received study cells and the other group received a comparison injection without cells into a blood vessel in the arm. After that, we looked at it up to 52 weeks.
- How many people participated?
- 35 people, 25 cells for research / 10 people for comparison injection
- How did you divide it?
- Divided into two groups like a lottery
- What did you do?
- Research cells (Muse) obtained from a donor are placed once into a blood vessel in the arm.
- When did you see the results?
- Compare mainly after 12 weeks / Check up to 52 weeks
Proportion of people able to live on their own after 12 weeks40% / 10%40% cells for research, 10% injections for comparison, difficult to see a clear difference
Cell groups for research40%
Comparison injection group10%
Total disability after 12 weeksobserve the differenceScores that look at the help needed for walking and daily life
Proportion of people able to live on their own after 52 weeks68.2% / 37.5%15/22 research cells · 3/8 comparative injections · Additional results
Cell groups for research68.2%
Comparison injection group37.5%
research 03
If you solve it easily,
You can look at the result like this.
Some disability scores and arm movements improved. However, most importantly, there was no clear difference between the two groups in the percentage of people who were able to live alone after 12 weeks. A larger study is needed due to the small number of participants.
Original sourceView the original text and research information
Original text of 35 research papersJ Cereb Blood Flow Metab · 2023 · doi:10.1177/0271678X231202594The two groups were not in the same condition at the start of the study. There was also one severe seizure that lasted a long time.